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faki pf 573228  (Selleck Chemicals)
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Selleck Chemicals faki pf 573228
Inhibition of focal adhesion kinase decreases focal adhesions, nuclear confinement and nuclear blebbing. (A) Example images of HT1080 FUCCI G1 nuclei, as determined by Cdt1 fluorescence and immunofluorescence of paxillin focal adhesions. (B) Graph of paxillin focal adhesions per cell area in G1 and late S/G2 nuclei without (−) or with (+) 5 µM FAKi <t>PF-573228.</t> n =40, 19, 16, 22, respectively. (C) Graph of nuclear height for G1 and late S/G2 cells treated without or with 5 µM FAKi PF-573228 ( n =12, 28, 15, 28, respectively). (D) Graph of nuclear blebbing percentages in HT1080 FUCCI treated with VPA and without (−) or with (+) 5 µM FAKi PF-573228. Results are for one biological replicate with n >200. * P <0.05; ** P <0.01 (unpaired two-tailed Student's t -test). Error bars represent s.e.m. Scale bars: 10 µm.
Faki Pf 573228, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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faki pf 573228 - by Bioz Stars, 2026-05
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cells  (Selleck Chemicals)
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Selleck Chemicals cells
Inhibition of focal adhesion kinase decreases focal adhesions, nuclear confinement and nuclear blebbing. (A) Example images of HT1080 FUCCI G1 nuclei, as determined by Cdt1 fluorescence and immunofluorescence of paxillin focal adhesions. (B) Graph of paxillin focal adhesions per cell area in G1 and late S/G2 nuclei without (−) or with (+) 5 µM FAKi <t>PF-573228.</t> n =40, 19, 16, 22, respectively. (C) Graph of nuclear height for G1 and late S/G2 cells treated without or with 5 µM FAKi PF-573228 ( n =12, 28, 15, 28, respectively). (D) Graph of nuclear blebbing percentages in HT1080 FUCCI treated with VPA and without (−) or with (+) 5 µM FAKi PF-573228. Results are for one biological replicate with n >200. * P <0.05; ** P <0.01 (unpaired two-tailed Student's t -test). Error bars represent s.e.m. Scale bars: 10 µm.
Cells, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cells/product/Selleck Chemicals
Average 95 stars, based on 1 article reviews
cells - by Bioz Stars, 2026-05
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pf 573228  (Selleck Chemicals)
95
Selleck Chemicals pf 573228
Inhibition of focal adhesion kinase decreases focal adhesions, nuclear confinement and nuclear blebbing. (A) Example images of HT1080 FUCCI G1 nuclei, as determined by Cdt1 fluorescence and immunofluorescence of paxillin focal adhesions. (B) Graph of paxillin focal adhesions per cell area in G1 and late S/G2 nuclei without (−) or with (+) 5 µM FAKi <t>PF-573228.</t> n =40, 19, 16, 22, respectively. (C) Graph of nuclear height for G1 and late S/G2 cells treated without or with 5 µM FAKi PF-573228 ( n =12, 28, 15, 28, respectively). (D) Graph of nuclear blebbing percentages in HT1080 FUCCI treated with VPA and without (−) or with (+) 5 µM FAKi PF-573228. Results are for one biological replicate with n >200. * P <0.05; ** P <0.01 (unpaired two-tailed Student's t -test). Error bars represent s.e.m. Scale bars: 10 µm.
Pf 573228, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/pf 573228/product/Selleck Chemicals
Average 95 stars, based on 1 article reviews
pf 573228 - by Bioz Stars, 2026-05
95/100 stars
  Buy from Supplier
fak pf 573228  (Selleck Chemicals)
95
Selleck Chemicals fak pf 573228
Inhibition of focal adhesion kinase decreases focal adhesions, nuclear confinement and nuclear blebbing. (A) Example images of HT1080 FUCCI G1 nuclei, as determined by Cdt1 fluorescence and immunofluorescence of paxillin focal adhesions. (B) Graph of paxillin focal adhesions per cell area in G1 and late S/G2 nuclei without (−) or with (+) 5 µM FAKi <t>PF-573228.</t> n =40, 19, 16, 22, respectively. (C) Graph of nuclear height for G1 and late S/G2 cells treated without or with 5 µM FAKi PF-573228 ( n =12, 28, 15, 28, respectively). (D) Graph of nuclear blebbing percentages in HT1080 FUCCI treated with VPA and without (−) or with (+) 5 µM FAKi PF-573228. Results are for one biological replicate with n >200. * P <0.05; ** P <0.01 (unpaired two-tailed Student's t -test). Error bars represent s.e.m. Scale bars: 10 µm.
Fak Pf 573228, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/fak pf 573228/product/Selleck Chemicals
Average 95 stars, based on 1 article reviews
fak pf 573228 - by Bioz Stars, 2026-05
95/100 stars
  Buy from Supplier
inhibitor  (Selleck Chemicals)
95
Selleck Chemicals inhibitor
Inhibition of focal adhesion kinase decreases focal adhesions, nuclear confinement and nuclear blebbing. (A) Example images of HT1080 FUCCI G1 nuclei, as determined by Cdt1 fluorescence and immunofluorescence of paxillin focal adhesions. (B) Graph of paxillin focal adhesions per cell area in G1 and late S/G2 nuclei without (−) or with (+) 5 µM FAKi <t>PF-573228.</t> n =40, 19, 16, 22, respectively. (C) Graph of nuclear height for G1 and late S/G2 cells treated without or with 5 µM FAKi PF-573228 ( n =12, 28, 15, 28, respectively). (D) Graph of nuclear blebbing percentages in HT1080 FUCCI treated with VPA and without (−) or with (+) 5 µM FAKi PF-573228. Results are for one biological replicate with n >200. * P <0.05; ** P <0.01 (unpaired two-tailed Student's t -test). Error bars represent s.e.m. Scale bars: 10 µm.
Inhibitor, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 95 stars, based on 1 article reviews
inhibitor - by Bioz Stars, 2026-05
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Inhibition of focal adhesion kinase decreases focal adhesions, nuclear confinement and nuclear blebbing. (A) Example images of HT1080 FUCCI G1 nuclei, as determined by Cdt1 fluorescence and immunofluorescence of paxillin focal adhesions. (B) Graph of paxillin focal adhesions per cell area in G1 and late S/G2 nuclei without (−) or with (+) 5 µM FAKi PF-573228. n =40, 19, 16, 22, respectively. (C) Graph of nuclear height for G1 and late S/G2 cells treated without or with 5 µM FAKi PF-573228 ( n =12, 28, 15, 28, respectively). (D) Graph of nuclear blebbing percentages in HT1080 FUCCI treated with VPA and without (−) or with (+) 5 µM FAKi PF-573228. Results are for one biological replicate with n >200. * P <0.05; ** P <0.01 (unpaired two-tailed Student's t -test). Error bars represent s.e.m. Scale bars: 10 µm.

Journal: Journal of Cell Science

Article Title: Changes in nuclear and actin mechanics from G1 to G2 affect nuclear integrity

doi: 10.1242/jcs.264118

Figure Lengend Snippet: Inhibition of focal adhesion kinase decreases focal adhesions, nuclear confinement and nuclear blebbing. (A) Example images of HT1080 FUCCI G1 nuclei, as determined by Cdt1 fluorescence and immunofluorescence of paxillin focal adhesions. (B) Graph of paxillin focal adhesions per cell area in G1 and late S/G2 nuclei without (−) or with (+) 5 µM FAKi PF-573228. n =40, 19, 16, 22, respectively. (C) Graph of nuclear height for G1 and late S/G2 cells treated without or with 5 µM FAKi PF-573228 ( n =12, 28, 15, 28, respectively). (D) Graph of nuclear blebbing percentages in HT1080 FUCCI treated with VPA and without (−) or with (+) 5 µM FAKi PF-573228. Results are for one biological replicate with n >200. * P <0.05; ** P <0.01 (unpaired two-tailed Student's t -test). Error bars represent s.e.m. Scale bars: 10 µm.

Article Snippet: Cells were treated with 5–10 μM FAKi PF-573228 (869288-64-2, Selleckchem) from a 5 mM dilution in DMSO.

Techniques: Inhibition, Fluorescence, Immunofluorescence, Two Tailed Test